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Chris: Yeah, thats a great question

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

When SAH is high, methylation reactions are decreased, reducing the conversion of methionine to SAMe and methyl groups

Y., Wu J

Release of IL-1 into the medium and cleavage of IL-1 in the cell lysates were decreased 50% by HNE compared to control, but NLRP3 and pro-IL-1 protein levels did not change (Fig